DPYD-IT1

Across TCGA pan-cancer cohorts, DPYD-IT1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated DPYD-IT1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher DPYD-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DPYD-IT1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and STAD show a favorable association.

KICH, ESCA, and TGCT are the cancer types where DPYD-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.578	0.938	<.001	97	view →
ESCA	DFS	Median	III,IV	0.621	0.266	<.001	62	view →
TGCT	OS	Tertile	All	0.876	0.975	.005	54	view →
KIRC	DFS	Quartile	All	0.535	0.683	<.001	40	view →
COAD	OS	Tertile	II,III,IV	0.272	0.676	.010	21	view →
GBM	OS	Tertile	All	0.197	0.471	<.001	18	view →
CHOL	OS	Tertile	II,III,IV	0.024	0.601	.025	18	view →
MESO	OS	Tertile	All	0.169	0.617	.006	18	view →
UCS	OS	Tertile	All	0.409	0.605	.048	18	view →
ACC	DFS	Tertile	III,IV	0.033	0.381	<.001	18	view →
UCEC	DFS	Tertile	All	0.825	0.903	.020	18	view →
STAD	OS	Median	II,III,IV	0.492	0.349	.011	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

DPYD-IT1–KICH (DFS)

Open the KICH breakdown →