DPYD-IT1

Across TCGA pan-cancer cohorts, DPYD-IT1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of DPYD-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where DPYD-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types DPYD-IT1 is over-expressed in tumor, although a few such as BLCA show the opposite, repressed pattern.

BLCA and LUAD are the cancer types where DPYD-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DPYD-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Female	III,IV	−0.190	.005	3	view →
LUAD	All	All	+0.214	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

DPYD-IT1–BLCA

Open the BLCA breakdown →