DPYD-AS2

Across TCGA pan-cancer cohorts, DPYD-AS2 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated DPYD-AS2 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher DPYD-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DPYD-AS2 expression acts as an unfavorable survival marker, although some lineages such as MESO and ESCA show a favorable association.

KICH, THYM, and READ are the cancer types where DPYD-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.600	0.953	<.001	106	view →
THYM	OS	Tertile	All	0.818	1.000	<.001	90	view →
READ	DFS	Tertile	All	0.261	0.709	<.001	54	view →
UVM	DFS	Tertile	All	0.032	0.762	<.001	45	view →
MESO	OS	Tertile	All	0.577	0.320	.005	36	view →
DLBC	OS	Tertile	II,III,IV	0.520	1.000	.003	30	view →
ESCA	DFS	Quartile	III,IV	0.580	0.217	.004	27	view →
ACC	DFS	Quartile	III,IV	0.028	0.351	<.001	25	view →
GBM	OS	Tertile	All	0.528	0.264	.010	21	view →
UCEC	DFS	Tertile	II,III,IV	0.125	0.523	.028	18	view →
LGG	DFS	Tertile	All	0.711	0.847	.004	15	view →
HNSC	DFS	Quartile	All	0.724	0.592	.009	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

DPYD-AS2–KICH (DFS)

Open the KICH breakdown →