DPYD-AS1

Across TCGA pan-cancer cohorts, DPYD-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated DPYD-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DPYD-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DPYD-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and ESCA show a favorable association.

KIRC, BRCA, and ESCA are the cancer types where DPYD-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.717	0.853	<.001	79	view →
BRCA	DFS	Median	All	0.964	0.933	.007	41	view →
ESCA	DFS	Tertile	III,IV	0.637	0.276	<.001	35	view →
HNSC	OS	Tertile	III,IV	0.693	0.827	.002	33	view →
STAD	DFS	Median	All	0.604	0.802	.007	31	view →
LGG	OS	Median	All	0.757	0.861	.002	26	view →
COAD	DFS	Tertile	All	0.332	0.636	.004	20	view →
THCA	OS	Quartile	III,IV	0.646	0.934	.005	17	view →
LIHC	OS	Tertile	III,IV	0.747	0.290	.003	12	view →
SKCM	OS	Median	II,III,IV	0.887	0.793	.010	12	view →
LUAD	OS	Median	III,IV	0.777	0.519	.005	9	view →
DLBC	DFS	Tertile	All	0.858	0.360	.019	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

DPYD-AS1–KIRC (DFS)

Open the KIRC breakdown →