DPYD-AS1

Across TCGA pan-cancer cohorts, DPYD-AS1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of DPYD-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DPYD-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DPYD-AS1 is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

LUAD, LUSC, and BRCA are the cancer types where DPYD-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DPYD-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.688	<.001	6	view →
LUSC	All	All	−0.195	<.001	4	view →
BRCA	All	III,IV	−0.129	<.001	2	view →
UCEC	All	All	−0.086	.046	2	view →
KIRC	Male	IV	+0.044	.032	1	view →
HNSC	Male	All	+0.044	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

DPYD-AS1–LUAD

Open the LUAD breakdown →