DPY19L3

Across TCGA patient cohorts, DPY19L3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPY19L3-associated genes across cancer lineages are FOXO3a_pS318_S321, Ku80, and p38-MAPK_pT180_Y182. Each is linked with DPY19L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPY19L3-to-partner and partner-to-DPY19L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by DPY19L3-low versus DPY19L3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPY19L3→partner) and Y-score (partner→DPY19L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.197	-3.087	<.001	<.001	3	2
UCEC	Ku80 →	+0.287	+3.100	.002	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.420	-1.893	.020	.016	3	2
UCEC	Src_pY527 →	-0.468	-2.212	.006	.010	3	2
UCEC	EGFR_pY1068 →	-0.315	-4.169	.001	<.001	3	1
UCEC	EGFR →	-0.158	-2.973	.013	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

FOXO3a_pS318_S321 by DPY19L3 expression — UCEC

Explore this box plot interactively →