DPY19L3

Across TCGA pan-cancer cohorts, DPY19L3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated DPY19L3 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DPY19L3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated DPY19L3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and THYM show a favorable association.

HNSC, LGG, and THYM are the cancer types where DPY19L3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.779	0.622	<.001	109	view →
LGG	DFS	Tertile	All	0.641	0.813	<.001	47	view →
THYM	DFS	Quartile	All	0.804	0.542	.003	39	view →
UCS	DFS	Tertile	III,IV	0.489	0.134	.010	32	view →
STAD	OS	Quartile	All	0.619	0.861	.016	25	view →
PAAD	DFS	Quartile	All	0.595	0.349	.014	25	view →
SARC	OS	Tertile	All	0.355	0.598	.003	21	view →
COAD	DFS	Quartile	III,IV	0.422	0.666	.010	21	view →
READ	OS	Median	All	0.870	0.325	.013	20	view →
UVM	DFS	Quartile	III,IV	0.234	0.740	.017	19	view →
PRAD	DFS	Quartile	All	0.970	0.843	<.001	18	view →
LAML	DFS	Median	All	0.545	0.382	.021	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

DPY19L3–HNSC (DFS)

Open the HNSC breakdown →