DPPA5P4

Across TCGA pan-cancer cohorts, DPPA5P4 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated DPPA5P4 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher DPPA5P4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DPPA5P4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

LUSC, MESO, and DLBC are the cancer types where DPPA5P4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Quartile	III,IV	0.351	0.854	.005	66	view →
MESO	OS	Tertile	II,III,IV	0.258	0.587	<.001	54	view →
DLBC	OS	Tertile	II,III,IV	0.172	0.949	<.001	54	view →
COAD	DFS	Tertile	III,IV	0.335	0.665	.003	54	view →
SKCM	DFS	Tertile	All	0.834	0.698	.001	51	view →
ACC	OS	Tertile	All	0.227	0.728	.012	48	view →
UVM	DFS	Tertile	III,IV	0.161	0.702	.005	45	view →
BRCA	DFS	Tertile	All	0.570	1.000	.033	36	view →
ESCA	OS	Quartile	All	0.470	1.000	<.001	30	view →
KICH	DFS	Tertile	All	0.521	0.969	.037	27	view →
CHOL	OS	Tertile	II,III,IV	0.024	0.601	.025	18	view →
CESC	OS	Tertile	III,IV	0.925	0.281	.018	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

DPPA5P4–LUSC (OS)

Open the LUSC breakdown →