DPPA5P4

Across TCGA pan-cancer cohorts, DPPA5P4 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of DPPA5P4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DPPA5P4 RNA is repressed in tumor relative to normal tissue. In most cancer types DPPA5P4 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, BRCA, and LUSC are the cancer types where DPPA5P4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DPPA5P4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.948	<.001	11	view →
BRCA	Female	All	−0.086	<.001	4	view →
LUSC	Male	All	−0.108	.027	1	view →
LIHC	Male	II,III,IV	−0.070	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

DPPA5P4–THCA

Open the THCA breakdown →