DPPA4

Across TCGA patient cohorts, DPPA4 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPPA4-associated genes across cancer lineages are Caspase-7-cleavedD198, Caveolin-1, and ERK2. Each is linked with DPPA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both DPPA4-to-partner and partner-to-DPPA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DPPA4-low versus DPPA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPPA4→partner) and Y-score (partner→DPPA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.623	+2.000	.019	.032	3	3
SKCM	Caveolin-1 →	-0.500	-1.678	.035	.022	3	2
UCEC	ERK2 →	+0.232	+2.000	.007	.032	3	2
UCEC	ATM →	-0.522	-3.169	.010	.019	3	2
UCEC	Cyclin-E2 →	+0.177	+2.000	.020	.032	3	2
LUSC	FoxM1 →	+0.285	+3.188	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Caspase-7-cleavedD198 by DPPA4 expression — UCEC

Explore this box plot interactively →