DPPA4

Across TCGA pan-cancer cohorts, DPPA4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated DPPA4 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DPPA4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DPPA4 expression acts as an unfavorable survival marker, although some lineages such as SCLC and COAD show a favorable association.

KIRC, LGG, and SCLC are the cancer types where DPPA4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Quartile	All	0.534	0.722	<.001	88	view →
LGG	DFS	Median	All	0.646	0.819	<.001	53	view →
SCLC	DFS	Quartile	II,III,IV	0.868	0.424	.001	48	view →
UCS	OS	Quartile	All	0.505	0.810	.016	28	view →
COAD	DFS	Quartile	All	0.889	0.733	.006	26	view →
ACC	OS	Tertile	II,III,IV	0.639	1.000	.004	25	view →
ESCA	OS	Median	III,IV	0.581	0.310	.004	18	view →
MESO	OS	Tertile	All	0.214	0.748	.001	18	view →
THYM	OS	Median	All	0.966	0.757	.002	18	view →
LAML	DFS	Median	All	0.353	0.575	.013	16	view →
LIHC	DFS	Tertile	II,III,IV	0.327	0.584	.017	8	view →
PAAD	DFS	Median	All	0.144	0.332	.027	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

DPPA4–KIRC (OS)

Open the KIRC breakdown →