DPPA4

Across TCGA cell cohorts, DPPA4 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DPPA4-associated genes across cancer lineages are NLRP7, TAFA1, and CLPSL1. Each is linked with DPPA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPPA4-to-partner and partner-to-DPPA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP7 grouped by DPPA4-low versus DPPA4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPPA4→partner) and Y-score (partner→DPPA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NLRP7 →	+0.853	+3.648	.002	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
LARGE_INTESTINE	CLPSL1 →	+0.118	+2.791	<.001	.005	3	1
LARGE_INTESTINE	LRRC3C →	+0.226	+3.099	.002	.004	3	1
LARGE_INTESTINE	IBSP →	+0.196	+3.257	<.001	.001	3	1
LARGE_INTESTINE	CHAT →	+0.023	+2.688	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

NLRP7 by DPPA4 expression — LARGE_INTESTINE

Explore this box plot interactively →