Across TCGA pan-cancer cohorts, DPPA3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DPPA3 data layer compared with 14 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher DPPA3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DPPA3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

STAD, LUSC, and SKCM are the cancer types where DPPA3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.250	0.689	.005	24	view →
LUSC	DFS	Median	III,IV	0.138	0.670	<.001	24	view →
SKCM	DFS	Median	All	0.208	0.646	.001	18	view →
UCEC	DFS	Median	All	1.000	0.617	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: DPPA3 tumor-vs-normal RNA expression · all DPPA3 data types