Across TCGA pan-cancer cohorts, DPPA3 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of DPPA3’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where DPPA3 RNA is repressed in tumor relative to normal tissue. In most cancer types DPPA3 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

LUSC, ESCA, and HNSC are the cancer types where DPPA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DPPA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	−0.151	<.001	2	view →
ESCA	All	II,III,IV	+0.075	.037	2	view →
HNSC	Female	All	+0.028	.016	2	view →
THCA	All	All	−0.026	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: DPPA3 RNA expression & survival · all DPPA3 data types