DPPA2

Across TCGA patient cohorts, DPPA2 mutation is significantly associated with the immune_cell of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPPA2-associated genes across cancer lineages are Platelets, MEP, and Macrophages. Each is linked with DPPA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DPPA2-to-partner and partner-to-DPPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Platelets grouped by DPPA2-low versus DPPA2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPPA2→partner) and Y-score (partner→DPPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	Platelets →	+0.026	+3.100	<.001	.017	3	3
LUSC	MEP →	+0.022	+3.214	.020	.009	3	2
SKCM	Macrophages →	-0.024	-1.726	.007	.024	3	1
SKCM	Macrophages M2 →	-0.016	-1.251	.008	.013	3	1
UCEC	aDC →	+0.101	+2.177	.004	.035	2	2
UCEC	CD8+ naive T-cells →	+0.042	+3.032	.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Platelets by DPPA2 expression — HNSC

Explore this box plot interactively →