DPPA2

Across TCGA pan-cancer cohorts, DPPA2 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated DPPA2 data layer compared with 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher DPPA2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DPPA2 expression acts as an unfavorable survival marker, although some lineages such as SCLC and KIRP show a favorable association.

COAD, MESO, and SCLC are the cancer types where DPPA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	All	0.714	0.884	<.001	138	view →
MESO	DFS	Tertile	All	0.257	0.416	.005	63	view →
SCLC	DFS	Tertile	II,III,IV	0.839	0.332	.010	51	view →
LAML	DFS	Median	All	0.422	0.664	<.001	36	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	28	view →
KIRP	DFS	Quartile	All	1.000	0.628	.020	26	view →
THYM	OS	Median	All	0.962	0.770	.009	13	view →
LIHC	OS	Tertile	II,III,IV	0.255	0.464	.019	12	view →
BLCA	OS	Quartile	All	0.616	0.744	.018	12	view →
GBM	DFS	Tertile	All	0.132	0.309	.022	9	view →
KIRC	DFS	Median	All	0.914	0.850	.009	8	view →
TGCT	DFS	Quartile	All	0.647	0.862	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

DPPA2–COAD (OS)

Open the COAD breakdown →