DPPA2

Across TCGA cell cohorts, DPPA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 199 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DPPA2-associated GO terms across cancer lineages are Negative regulation of heart rate, Regulation of sodium ion transmembrane transport, and Negative regulation of interleukin-12 production. Each is linked with DPPA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DPPA2-to-partner and partner-to-DPPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of heart rate grouped by DPPA2-low versus DPPA2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DPPA2→partner) and Y-score (partner→DPPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of heart rate →	-0.244	-0.081	<.001	.003	3	2
LARGE_INTESTINE	Regulation of sodium ion transmembrane transport →	-0.077	-0.062	.004	.005	3	2
OVARY	Negative regulation of interleukin-12 production →	-0.157	-1.509	<.001	.007	3	2
OVARY	Toll-like receptor 2 signaling pathway →	+0.166	+1.795	<.001	.009	3	2
OVARY	Negative regulation of epidermal growth factor receptor signaling pathway →	+0.075	+1.505	<.001	.009	3	2
KIDNEY	Negative regulation of heart contraction →	-0.121	-0.014	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 199 associations by consensus.

Negative regulation of heart rate by DPPA2 expression — LARGE_INTESTINE

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