Across TCGA cell cohorts, DPP4 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DPP4-associated genes across cancer lineages are GNG8, EPO, and SULT6B1. Each is linked with DPP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPP4-to-partner and partner-to-DPP4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPP4→partner) and Y-score (partner→DPP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GNG8 →	+1.361	+4.643	<.001	.003	3	2
LARGE_INTESTINE	EPO →	+0.178	+3.389	<.001	.007	3	1
LARGE_INTESTINE	SULT6B1 →	+0.021	+2.977	<.001	.006	3	1
LARGE_INTESTINE	PNLDC1 →	+0.083	+3.302	<.001	.008	3	1
LARGE_INTESTINE	SGSM1 →	+0.525	+3.302	<.001	.008	3	1
LARGE_INTESTINE	UBTD2 →	+0.536	+3.064	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

DPP4 survival (RNA) · tumor vs normal (RNA) · all DPP4 data types