DPP4-DT

Across TCGA pan-cancer cohorts, DPP4-DT RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of DPP4-DT’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DPP4-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DPP4-DT is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

THCA, LUAD, and KICH are the cancer types where DPP4-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DPP4-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+1.945	<.001	11	view →
LUAD	Female	All	+0.596	<.001	7	view →
KICH	Female	All	−0.273	<.001	7	view →
UCEC	All	All	−0.466	<.001	6	view →
BRCA	All	II,III,IV	−0.346	<.001	6	view →
KIRC	All	III,IV	+0.131	.005	6	view →
LIHC	All	All	+0.184	.002	2	view →
ESCA	All	All	+0.301	.017	1	view →
LUSC	All	All	−0.199	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

DPP4-DT–THCA

Open the THCA breakdown →