DPH6

Across TCGA patient cohorts, DPH6 mutation is significantly associated with the RNA expression of many other genes, with 2,141 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPH6-associated genes across cancer lineages are MIR3651, LINC02634, and PTPRJ. Each is linked with DPH6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPH6-to-partner and partner-to-DPH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3651 grouped by DPH6-low versus DPH6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPH6→partner) and Y-score (partner→DPH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3651 →	+0.375	+2.063	.004	.001	3	2
SKCM	LINC02634 →	+0.167	+3.287	.002	.008	3	2
UCEC	PTPRJ →	+0.694	+2.724	.001	.003	3	1
UCEC	INTS4 →	+0.328	+2.724	.007	.003	3	1
UCEC	MTA2 →	+0.472	+3.963	<.001	<.001	3	1
UCEC	TMEM138 →	+0.295	+3.609	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,141 associations by consensus.

MIR3651 by DPH6 expression — UCEC

Explore this box plot interactively →