DPH6-DT

Across TCGA pan-cancer cohorts, DPH6-DT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DPH6-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DPH6-DT RNA is repressed in tumor relative to normal tissue. In most cancer types DPH6-DT is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LUAD are the cancer types where DPH6-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DPH6-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−0.899	<.001	11	view →
KICH	Male	All	−1.327	<.001	9	view →
LUAD	Female	III,IV	−0.597	<.001	9	view →
THCA	Male	III,IV	−0.878	<.001	8	view →
BRCA	All	III,IV	−0.287	<.001	8	view →
LUSC	All	III,IV	−0.930	<.001	7	view →
KIRP	Male	III,IV	−1.151	<.001	6	view →
UCEC	All	II,III,IV	−0.802	<.001	6	view →
STAD	Female	All	−0.231	.005	5	view →
LIHC	All	All	+0.301	<.001	4	view →
READ	All	All	−0.245	.019	4	view →
PAAD	Female	All	−0.555	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DPH6-DT–KIRC

Open the KIRC breakdown →