DPH1

Across TCGA patient cohorts, DPH1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPH1-associated genes across cancer lineages are PCNA, ATM, and eIF4E. Each is linked with DPH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DPH1-to-partner and partner-to-DPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by DPH1-low versus DPH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPH1→partner) and Y-score (partner→DPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.232	+3.169	.009	.018	3	3
UCEC	ATM →	-0.712	-2.321	<.001	.006	3	2
UCEC	eIF4E →	+0.181	+3.013	.038	.018	3	1
UCEC	INPP4B →	-0.273	-2.459	.041	.018	3	1
UCEC	JNK2 →	+0.244	+2.321	.002	.006	3	1
UCEC	Notch1 →	+0.156	+1.807	.007	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

PCNA by DPH1 expression — UCEC

Explore this box plot interactively →