DPF2

Across TCGA patient cohorts, DPF2 mutation is significantly associated with the RNA expression of many other genes, with 1,852 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPF2-associated genes across cancer lineages are POLR2A, MRPS11, and LCK. Each is linked with DPF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPF2-to-partner and partner-to-DPF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLR2A grouped by DPF2-low versus DPF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPF2→partner) and Y-score (partner→DPF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLR2A →	+0.627	+2.839	.002	.001	3	2
UCEC	MRPS11 →	+0.302	+2.333	.009	<.001	3	2
UCEC	LCK →	+0.691	+3.592	.002	.001	3	2
UCEC	VPS33B →	+0.296	+2.269	.003	.001	3	2
UCEC	ANP32BP1 →	+0.223	+2.280	.008	.001	3	2
SKCM	RNU6-1123P →	+0.497	+5.452	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,852 associations by consensus.

POLR2A by DPF2 expression — UCEC

Explore this box plot interactively →