DPAGT1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, DPAGT1 mutation is significantly associated with the RNA expression of many other genes, with 1,275 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPAGT1-associated genes across cancer lineages are OR10AE1P, MIR7158, and ZNF530. Each is linked with DPAGT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPAGT1-to-partner and partner-to-DPAGT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10AE1P grouped by DPAGT1-low versus DPAGT1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPAGT1→partner) and Y-score (partner→DPAGT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
READOR10AE1P →+0.189+6.681<.001<.00132
KIRCMIR7158 →+0.651+6.429<.001<.00132
UCECZNF530 →+0.398+1.936.001.00332
UCECCIDECP1 →+0.480+3.892<.001<.00132
UCECSREBF2 →+0.454+2.254.009.00532
UCECRN7SKP181 →+0.082+2.207.002.00632
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,275 associations by consensus.

OR10AE1P by DPAGT1 expression — READ

Box plot of OR10AE1P in DPAGT1-low vs DPAGT1-high samples in READ.

Explore this box plot interactively →

Exploration