DPAGT1

Across TCGA pan-cancer cohorts, DPAGT1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated DPAGT1 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher DPAGT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DPAGT1 expression acts as an unfavorable survival marker, although some lineages such as STAD and PAAD show a favorable association.

LGG, UVM, and ACC are the cancer types where DPAGT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.744	0.884	<.001	52	view →
UVM	DFS	Quartile	All	0.283	0.868	<.001	49	view →
ACC	DFS	Quartile	All	0.159	0.781	<.001	48	view →
LIHC	DFS	Tertile	All	0.441	0.616	<.001	42	view →
STAD	OS	Quartile	All	0.619	0.335	.005	34	view →
BRCA	OS	Median	II,III,IV	0.891	0.932	.010	32	view →
CESC	DFS	Quartile	All	0.436	0.732	<.001	24	view →
LUSC	DFS	Quartile	II,III,IV	0.601	0.824	.002	22	view →
BLCA	OS	Quartile	All	0.234	0.630	.002	18	view →
DLBC	DFS	Quartile	II,III,IV	0.335	0.984	.022	18	view →
SARC	OS	Median	All	0.678	0.803	.005	16	view →
HNSC	OS	Tertile	All	0.696	0.804	.003	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

DPAGT1–LGG (OS)

Open the LGG breakdown →