DPAGT1

Across TCGA patient cohorts, DPAGT1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPAGT1-associated genes across cancer lineages are MIG-6, PDCD4, and 14-3-3_beta. Each is linked with DPAGT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DPAGT1-to-partner and partner-to-DPAGT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by DPAGT1-low versus DPAGT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPAGT1→partner) and Y-score (partner→DPAGT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIG-6 →	+0.080	+2.594	.031	.006	3	3
UCEC	PDCD4 →	-0.456	-1.990	.009	.030	3	2
UCEC	14-3-3_beta →	-0.088	-1.847	.019	.049	3	1
UCEC	eEF2 →	+0.384	+3.321	.004	.009	3	1
UCEC	EGFR →	-0.177	-3.143	.003	.018	3	1
UCEC	A-Raf_pS299 →	-0.133	-1.765	.002	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

MIG-6 by DPAGT1 expression — UCEC

Explore this box plot interactively →