DOT1L

Across TCGA patient cohorts, DOT1L protein abundance is significantly associated with the RNA expression of many other genes, with 4,906 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DOT1L-associated genes across cancer lineages are CCNB1, TOP2A, and KIF2C. Each is linked with DOT1L in more than 3 cancer types. Because this analysis shows association rather than direction, both DOT1L-to-partner and partner-to-DOT1L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DOT1L versus CCNB1 in UCEC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOT1L→partner) and Y-score (partner→DOT1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCNB1 →	+1.022	+0.365	<.001	<.001	3	3
UCEC	TOP2A →	+1.281	+0.381	<.001	.006	3	3
UCEC	KIF2C →	+1.350	+0.421	<.001	.001	3	3
UCEC	PBK →	+1.675	+0.402	<.001	<.001	3	3
UCEC	CBX2 →	+1.255	+0.472	<.001	<.001	3	3
UCEC	FANCB →	+0.838	+0.512	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,906 associations by consensus.

DOT1L vs CCNB1 — UCEC

Explore this scatter interactively →