DOP1A

Across TCGA pan-cancer cohorts, DOP1A Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated DOP1A data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DOP1A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated DOP1A expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, SCLC, and LIHC are the cancer types where DOP1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.776	0.625	.003	36	view →
SCLC	DFS	Median	III,IV	0.082	0.548	.003	24	view →
LIHC	DFS	Median	III,IV	0.076	0.360	.001	24	view →
READ	OS	Median	II,III,IV	0.054	0.934	<.001	16	view →
SKCM	OS	Median	II,III,IV	0.921	0.722	.026	8	view →
STAD	OS	Median	IV	0.805	0.283	.031	7	view →
ACC	DFS	Median	All	0.218	0.765	<.001	6	view →
KIRC	OS	Median	II,III,IV	0.182	0.696	.046	3	view →
LUSC	DFS	Median	III,IV	0.262	0.644	.017	3	view →
BLCA	DFS	Median	III,IV	1.000	0.181	.047	2	view →
GBM	DFS	Median	All	1.000	0.248	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

DOP1A–UCEC (DFS)

Open the UCEC breakdown →