DOP1A

Across TCGA pan-cancer cohorts, DOP1A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DOP1A data layer compared with 21 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher DOP1A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DOP1A expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

GBM, LUAD, and CCRCC are the cancer types where DOP1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.872	0.566	.002	19	view →
LUAD	OS	Quartile	All	0.962	0.676	.002	15	view →
CCRCC	OS	Median	All	1.000	0.872	.004	12	view →
LSCC	DFS	Median	III,IV	0.930	0.672	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DOP1A–GBM (DFS)

Open the GBM breakdown →