DOP1A

Across TCGA patient cohorts, DOP1A mutation is significantly associated with the RNA expression of many other genes, with 4,506 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOP1A-associated genes across cancer lineages are MTHFD2, CD207, and WNT5B. Each is linked with DOP1A in more than 4 cancer types. Because this analysis shows association rather than direction, both DOP1A-to-partner and partner-to-DOP1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTHFD2 grouped by DOP1A-low versus DOP1A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOP1A→partner) and Y-score (partner→DOP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTHFD2 →	+0.691	+3.726	<.001	<.001	3	5
CESC	CD207 →	-1.243	-3.575	.008	.002	3	4
BLCA	WNT5B →	-1.128	-2.668	.003	.005	3	4
COAD	HELLS →	+0.580	+2.807	<.001	.003	3	4
STAD	PIMREG →	+0.972	+3.338	<.001	.005	2	5
COAD	NUSAP1 →	+0.552	+3.196	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,506 associations by consensus.

MTHFD2 by DOP1A expression — COAD

Explore this box plot interactively →