DOP1A

Across TCGA cell cohorts, DOP1A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,724 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DOP1A-associated GO terms across cancer lineages are Golgi to endosome transport, Regulation of organelle assembly, and Regulation of alternative mRNA splicing, via spliceosome. Each is linked with DOP1A in more than 16 cancer types. Because this analysis shows association rather than direction, both DOP1A-to-partner and partner-to-DOP1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi to endosome transport grouped by DOP1A-low versus DOP1A-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DOP1A→partner) and Y-score (partner→DOP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Golgi to endosome transport →	+0.116	+0.710	<.001	.001	3	17
LUNG_SCLC	Regulation of organelle assembly →	+0.046	+0.918	<.001	.002	3	15
LUNG_SCLC	Regulation of alternative mRNA splicing, via spliceosome →	+0.119	+1.528	<.001	<.001	3	15
LUNG_SCLC	Regulation of nucleotide-excision repair →	+0.128	+1.043	<.001	.001	3	14
BREAST	Positive regulation of cilium assembly →	+0.100	+0.952	<.001	.003	3	14
STOMACH	Protein localization to cytoplasmic stress granule →	+0.179	+1.281	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,724 associations by consensus.

Golgi to endosome transport by DOP1A expression — PANCREAS

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