DONSON

Across TCGA patient cohorts, DONSON RNA expression is significantly associated with the protein abundance of many other proteins, with 17,306 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DONSON-associated proteins across cancer lineages are HAT1, MCM4, and MCM5. Each is linked with DONSON in more than 7 cancer types. Because this analysis shows association rather than direction, both DONSON-to-partner and partner-to-DONSON results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DONSON versus HAT1 in LSCC, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DONSON→partner) and Y-score (partner→DONSON) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HAT1 →	+0.440	+0.462	<.001	<.001	3	8
LUAD	MCM4 →	+0.702	+0.614	<.001	<.001	3	8
LUAD	MCM5 →	+0.677	+0.614	<.001	<.001	3	8
LUAD	MCM7 →	+0.702	+0.614	<.001	<.001	3	8
LSCC	MSH6 →	+0.583	+0.584	<.001	<.001	3	7
LUAD	CCNB1 →	+0.773	+0.527	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,306 associations by consensus.

DONSON vs HAT1 — LSCC

Explore this scatter interactively →