DOLPP1

Across TCGA patient cohorts, DOLPP1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOLPP1-associated genes across cancer lineages are ACC1, 14-3-3_beta, and eIF4E. Each is linked with DOLPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOLPP1-to-partner and partner-to-DOLPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by DOLPP1-low versus DOLPP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOLPP1→partner) and Y-score (partner→DOLPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.406	+1.700	.008	.044	3	2
UCEC	14-3-3_beta →	-0.124	-2.439	.003	.019	3	1
UCEC	eIF4E →	+0.225	+3.335	.011	.005	3	1
UCEC	eIF4G →	+0.283	+2.321	.032	.033	3	1
UCEC	GAPDH →	+0.528	+2.459	.020	.019	3	1
UCEC	JNK2 →	+0.251	+2.222	.002	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ACC1 by DOLPP1 expression — UCEC

Explore this box plot interactively →