DOLPP1

Across TCGA pan-cancer cohorts, DOLPP1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DOLPP1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where DOLPP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DOLPP1 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

BLCA, HNSC, and LUAD are the cancer types where DOLPP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DOLPP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.460	<.001	11	view →
HNSC	Male	III,IV	+0.941	<.001	11	view →
LUAD	Male	II,III,IV	+0.826	<.001	11	view →
COAD	All	IV	−0.632	<.001	11	view →
LUSC	Female	All	+1.287	<.001	8	view →
KIRP	Male	II,III,IV	+0.661	<.001	8	view →
LIHC	Female	All	+0.592	<.001	7	view →
UCEC	All	III,IV	+1.197	<.001	6	view →
BRCA	All	III,IV	+0.878	<.001	6	view →
KIRC	Male	II,III,IV	−0.358	<.001	6	view →
STAD	All	All	+0.796	.003	5	view →
THCA	All	IV	−0.539	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

DOLPP1–BLCA

Open the BLCA breakdown →