DOLK

Across TCGA pan-cancer cohorts, DOLK Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DOLK data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher DOLK Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DOLK expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

OV, BLCA, and LUSC are the cancer types where DOLK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	II,III,IV	0.256	0.541	.021	36	view →
BLCA	OS	Median	IV	0.082	0.590	<.001	18	view →
LUSC	OS	Median	All	0.172	0.762	.002	12	view →
UCEC	DFS	Median	II,III,IV	0.875	0.436	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DOLK–OV (DFS)

Open the OV breakdown →