DOLK

Across TCGA pan-cancer cohorts, DOLK mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DOLK data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DOLK mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DOLK expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, LSCC, and GBM are the cancer types where DOLK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.768	0.202	.001	18	view →
LSCC	OS	Median	II,III,IV	0.670	1.000	.016	7	view →
GBM	OS	Median	All	0.982	0.729	.005	5	view →
HNSC	OS	Median	II,III,IV	1.000	0.950	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DOLK–LUAD (DFS)

Open the LUAD breakdown →