Across TCGA cell cohorts, DOK6 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOK6-associated genes across cancer lineages are ASB17, OPN1MW3, and POM121L12. Each is linked with DOK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOK6-to-partner and partner-to-DOK6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK6→partner) and Y-score (partner→DOK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
LUNG_SCLC	OPN1MW3 →	+0.010	+4.643	<.001	.004	3	1
LUNG_NSCLC_LUAD	POM121L12 →	+0.022	+5.266	<.001	.001	3	1
LARGE_INTESTINE	HTN1 →	+0.382	+4.273	<.001	.006	3	1
LARGE_INTESTINE	RFPL3 →	+0.048	+4.095	<.001	.009	3	1
LARGE_INTESTINE	OR2M5 →	+0.016	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

DOK6 survival (RNA) · tumor vs normal (RNA) · all DOK6 data types