Across TCGA pan-cancer cohorts, DOK6 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DOK6’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where DOK6 RNA is repressed in tumor relative to normal tissue. In most cancer types DOK6 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.
BLCA, KICH, and THCA are the cancer types where DOK6 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DOK6 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.