DOK4

Across TCGA patient cohorts, DOK4 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,010 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible DOK4-associated proteins across cancer lineages are TDP1, TJP1, and SAMSN1. Each is linked with DOK4 in more than 4 cancer types. Because this analysis shows association rather than direction, both DOK4-to-partner and partner-to-DOK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DOK4 versus TDP1 in BRCA, with a Pearson correlation of -0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK4→partner) and Y-score (partner→DOK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TDP1 →	-0.307	-0.680	<.001	<.001	3	4
HNSC	TJP1 →	+0.265	+0.691	<.001	<.001	3	4
CCRCC	SAMSN1 →	-0.403	-0.512	.002	.001	3	4
LUAD	C1orf116 →	+0.752	+1.048	<.001	<.001	3	4
BRCA	ADD3 →	+0.447	+0.541	<.001	.003	3	4
PDAC	CES2 →	+0.695	+0.445	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,010 associations by consensus.

DOK4 vs TDP1 — BRCA

Explore this scatter interactively →