DOK4

Across TCGA patient cohorts, DOK4 protein abundance is significantly associated with the RNA expression of many other genes, with 6,168 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DOK4-associated genes across cancer lineages are SRSF9, AUH, and SKA1. Each is linked with DOK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOK4-to-partner and partner-to-DOK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DOK4 versus SRSF9 in LSCC, with a Pearson correlation of -0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK4→partner) and Y-score (partner→DOK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SRSF9 →	-0.692	-0.293	<.001	.003	3	2
LSCC	AUH →	-0.932	-0.350	.001	.004	3	2
LSCC	SKA1 →	-1.387	-0.381	<.001	.005	3	2
LSCC	PCGF6 →	-1.051	-0.293	.001	.003	3	2
LSCC	MAB21L3 →	+1.511	+0.350	.008	.006	3	2
LSCC	NDC80 →	-1.658	-0.431	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,168 associations by consensus.

DOK4 vs SRSF9 — LSCC

Explore this scatter interactively →