DOK4

Across TCGA cell cohorts, DOK4 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible DOK4-associated genes across cancer lineages are C1orf146, OR10R2, and NLRP2B. Each is linked with DOK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOK4-to-partner and partner-to-DOK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf146 grouped by DOK4-low versus DOK4-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK4→partner) and Y-score (partner→DOK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C1orf146 →	+0.040	+4.450	<.001	.004	3	1
LARGE_INTESTINE	OR10R2 →	+0.031	+4.977	<.001	.007	3	1
OVARY	NLRP2B →	+0.059	+4.392	<.001	.004	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

C1orf146 by DOK4 expression — OVARY

Explore this box plot interactively →