DOK3

Across TCGA cell cohorts, DOK3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOK3-associated genes across cancer lineages are H1-8, LCE2B, and SCN10A. Each is linked with DOK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOK3-to-partner and partner-to-DOK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H1-8 grouped by DOK3-low versus DOK3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOK3→partner) and Y-score (partner→DOK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	H1-8 →	+0.054	+4.887	<.001	.009	3	2
LUNG_NSCLC_LUAD	LCE2B →	+0.039	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	SCN10A →	+0.006	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.034	+4.887	<.001	.009	3	1
LARGE_INTESTINE	CPO →	+0.109	+3.514	.001	.007	3	1
LARGE_INTESTINE	ZNF57 →	+0.598	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

H1-8 by DOK3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →