DOHH

Across TCGA pan-cancer cohorts, DOHH Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DOHH data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher DOHH Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DOHH expression acts as an unfavorable survival marker.

STAD, COAD, and PRAD are the cancer types where DOHH Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	II,III,IV	0.003	0.677	<.001	24	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DOHH–STAD (OS)

Open the STAD breakdown →