DOHH

Across TCGA pan-cancer cohorts, DOHH RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DOHH’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DOHH RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DOHH is over-expressed in tumor.

COAD, KIRC, and STAD are the cancer types where DOHH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DOHH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.949	<.001	11	view →
KIRC	Male	III,IV	+0.486	<.001	11	view →
STAD	Male	II,III,IV	+1.177	<.001	10	view →
LIHC	Female	II,III,IV	+1.032	<.001	9	view →
HNSC	Male	III,IV	+0.902	<.001	8	view →
KIRP	All	II,III,IV	+0.431	.002	8	view →
BRCA	All	All	+0.339	.002	6	view →
CHOL	Male	All	+1.863	<.001	5	view →
LUSC	All	All	+0.462	<.001	5	view →
UCEC	All	All	+0.410	.025	2	view →
KICH	All	All	+0.391	.022	2	view →
ESCA	All	All	+0.802	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DOHH–COAD

Open the COAD breakdown →