DOHH

Across TCGA pan-cancer cohorts, DOHH mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DOHH data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DOHH mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DOHH expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

LSCC, UCEC, and LUAD are the cancer types where DOHH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.778	0.956	.001	25	view →
UCEC	DFS	Quartile	All	1.000	0.850	.017	6	view →
LUAD	DFS	Tertile	All	0.680	0.882	.014	5	view →
HNSC	DFS	Median	III,IV	1.000	0.908	.008	4	view →
PDAC	OS	Median	IV	0.395	0.937	.026	3	view →
CCRCC	OS	Median	II,III,IV	1.000	0.499	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DOHH–LSCC (OS)

Open the LSCC breakdown →