DOHH

Across TCGA patient cohorts, DOHH RNA expression is significantly associated with the mutation status of many other genes, with 10,518 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOHH-associated genes across cancer lineages are TTN, EPHA5, and TACC2. Each is linked with DOHH in more than 5 cancer types. Because this analysis shows association rather than direction, both DOHH-to-partner and partner-to-DOHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTN grouped by DOHH-low versus DOHH-high in UCEC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOHH→partner) and Y-score (partner→DOHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TTN →	+1.158	+0.365	<.001	<.001	3	6
CESC	EPHA5 →	+3.391	+0.569	.004	.004	3	5
UCEC	TACC2 →	+1.727	+0.401	<.001	<.001	3	5
UCEC	MUC17 →	+1.895	+0.457	<.001	<.001	3	5
UCEC	LRP2 →	+1.310	+0.381	<.001	<.001	3	5
BLCA	PCDH15 →	+2.098	+0.419	.002	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,518 associations by consensus.

TTN by DOHH expression — UCEC

Explore this box plot interactively →