DOHH

Across TCGA patient cohorts, DOHH mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DOHH-associated genes across cancer lineages are GMP, Monocytes, and B-cells. Each is linked with DOHH in more than 1 cancer types. Because this analysis shows association rather than direction, both DOHH-to-partner and partner-to-DOHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMP grouped by DOHH-low versus DOHH-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOHH→partner) and Y-score (partner→DOHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GMP →	+0.036	+2.806	.048	.040	3	1
SKCM	Monocytes →	+0.011	+4.810	<.001	.043	3	1
UCEC	B-cells →	+0.033	+2.381	.018	.007	3	1
UCEC	CD4+ memory T-cells →	+0.036	+2.424	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GMP by DOHH expression — SKCM

Explore this box plot interactively →