DOHH

Across TCGA cell cohorts, DOHH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,219 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DOHH-associated GO terms across cancer lineages are Cytoplasm protein quality control by the ubiquitin-proteasome system, Cytoplasm protein quality control, and Positive regulation of protein localization to chromatin. Each is linked with DOHH in more than 17 cancer types. Because this analysis shows association rather than direction, both DOHH-to-partner and partner-to-DOHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasm protein quality control by the ubiquitin-proteasome system grouped by DOHH-low versus DOHH-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DOHH→partner) and Y-score (partner→DOHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.168	+0.945	<.001	<.001	3	18
BONE	Cytoplasm protein quality control →	+0.141	+0.947	<.001	<.001	3	17
BONE	Positive regulation of protein localization to chromatin →	+0.177	+1.310	<.001	<.001	3	15
OESOPHAGUS	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.108	+0.917	.002	<.001	2	15
OESOPHAGUS	Electron transport coupled proton transport →	+0.108	+0.917	.002	<.001	2	15
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.166	+1.003	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,219 associations by consensus.

Cytoplasm protein quality control by the ubiquitin-proteasome system by DOHH expression — OESOPHAGUS

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