DOHH

Across TCGA cell cohorts, DOHH mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOHH-associated genes across cancer lineages are CXorf51A, TKTL2, and OR10A4. Each is linked with DOHH in more than 1 cancer types. Because this analysis shows association rather than direction, both DOHH-to-partner and partner-to-DOHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CXorf51A grouped by DOHH-low versus DOHH-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOHH→partner) and Y-score (partner→DOHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CXorf51A →	+0.153	+4.867	<.001	.009	3	1
LARGE_INTESTINE	TKTL2 →	+0.040	+3.187	<.001	.006	3	1
LARGE_INTESTINE	OR10A4 →	+0.052	+3.201	<.001	.001	3	1
LARGE_INTESTINE	OR4F21 →	+0.153	+3.141	<.001	.002	3	1
LARGE_INTESTINE	ELOA3DP →	+0.019	+2.688	<.001	.008	3	1
BLOOD_Leukemia	OR10T2 →	+0.889	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CXorf51A by DOHH expression — BLOOD_Lymphoma

Explore this box plot interactively →