DOHH

Across TCGA cell cohorts, DOHH mutation is significantly associated with the mutation status of many other genes, with 3,088 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOHH-associated genes across cancer lineages are SLC6A11, TMEM185B, and PNPLA5. Each is linked with DOHH in more than 2 cancer types. Because this analysis shows association rather than direction, both DOHH-to-partner and partner-to-DOHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC6A11 grouped by DOHH-low versus DOHH-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOHH→partner) and Y-score (partner→DOHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC6A11 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	TMEM185B →	+6.014	+6.014	.001	.001	1	3
LARGE_INTESTINE	PNPLA5 →	+3.000	+3.000	.003	.003	1	3
LARGE_INTESTINE	SORBS3 →	+3.736	+3.736	<.001	<.001	1	3
LARGE_INTESTINE	SLC35C2 →	+3.000	+3.000	.003	.003	1	3
BLOOD_Leukemia	ZNF614 →	+5.285	+5.285	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,088 associations by consensus.

SLC6A11 by DOHH expression — BLOOD_Lymphoma

Explore this box plot interactively →